Fibromyalgia,  Complex Regional Pain Syndrome,  Crohn's Disease,  Multiple Sclerosis,  and more

Depression, PTSD, Anxiety


The Taub Group - Charlotte, NC
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Low-Dose Naltrexone (LDN)
A Different Approach for Treating Chronic Pain

If other treatments for chronic pain conditions such as those listed above have not reached your goals, LDN treatments may have more to offer. LDN affects the central nervous system differently compared to most pain medication, and therefore offers results beyond what other treatments can achieve. LDN enhances your body's own endorphin response and directly reduces the production of chemicals that inflame nerves. The enhancement of the body's own endorphin response is part of what makes LDN effective for depression, PTSD, and anxiety as well. If you struggle with chronic pain or other conditions listed here, please contact The Taub Group now to schedule an evaluation.


Naltrexone is an inexpensive, generic drug more commonly used to moderate withdrawal symptoms. However, 21st-century research is showing that very low doses of naltrexone increase the body's production of endorphins and makes the body more responsive to those endorphins. Additionally, LDN influences glial cells to stop producing chemicals that inflame nerves. This nerve inflammation is thought to be a component in the chronic pain cycle. More traditional pain meds work by quieting the nerve fibers themselves. For some people, more is needed.

LDN Safety

A big advantage is that naltrexone is not an opiate. In fact, it is the opposite of an opiate. Naltrexone is an opiate-blocking drug. It is FDA-approved. LDN is not generally considered addictive. For some people, discontinuing LDN may be like quitting caffeine. Complaints involve headaches, concentration, and low energy for a few days. It may be okay to take LDN with other meds you are taking, and it may not. In consultation, we will be able to tell you if you should discontinue one or more of your current meds to use LDN.




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Research at Stanford University
LDN has been shown to reduce symptom severity in fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome.
LDN research in the Journal of Translational Medicine
Twenty-five percent of patients with inflammatory bowel disease went into remission. Seventy-five percent saw overall improvements.
LDN IBD research in the Journal of Crohn's and Colitis
IBD patients taking LDN reduced their other IBD medicine intake. "There was a striking magnitude of change for some of the observed therapeutic groups."
Brown University Medical Research
Complex Regional Pain Syndrome: LDN helps after conventional therapy failed.
Harvard Medical School Research
Low-Dose Naltrexone found to help patients on antidepressants after breakthrough symptoms.
Depression research with LDN
Scopolamine and naltrexone have rapid acting benefits for depression.
More Information about Low-Dose Naltrexone (LDN)

How Is LDN Different for Treating Chronic Pain?

Low-dose naltrexone increases the release of endorphins and lowers inflammation in the central nervous system. Inflammation of the central nervous system is believed to contribute to the chronic nature of some pain syndromes. Repeated or constant pain signals can trigger glial cells to release inflammatory chemicals that affect nerves. The resulting inflammation makes the central nervous system hypersensitive to pain. Traditional approaches to chronic pain have attempted to break this pain cycle by quieting pain signals from the nerves.

The traditional approach has sometimes involved opioid medications and their known dangers. Low-dose naltrexone works differently. Rather than quieting the nerve fibers, LDN affects the glial cells directly, influencing them to stop releasing the inflammatory chemicals. Reducing the inflammation helps the central nervous system return to normal function.


Learn More about Naltrexone in Behavioral Health

When pain syndromes have overlay with behavioral health challenges such as depression, anxiety, or PTSD, low-dose naltrexone provides additional advantages. By boosting the body's reaction to its own endorphins, this treatment protocol can upregulate mood as well.

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